Aquagenic Wrinkling of the Palms (also called Acquired Aquagenic Syringeal Acrokeratoderma) is a rare condition that I occasionally encounter in both my The Woodlands dermatology and Conroe dermatology offices. White papules occur on the palm of the hands 5-10 minutes after exposure to water and are very sharply demarcated from the rest of the skin. A large pore can be seen in the center of the white papules. The affected skin appears to have a macerated look as if the hands have been immersed in water for hours. It is commonly seen in patients with Cystic Fibrosis, but can be a hereditary condition that is transmitted through autosomal dominance meaning that it does not skip generations. Treatment is usually ineffective but Drysol (20% aluminum chloride) applied nightly to the palms typically is most effective.
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