June 7, 2014

| perri dermatology
Medically reviewed by Anthony J. Perri, M.D.

Malignant Fibrous Histiocytoma is a cancerous fibrous tissue abnormality that I rarely encounter in both my The Woodlands dermatology and Conroe dermatology offices.  Malignant Fibrous Histiocytoma is the most common soft tissue sarcoma in middle to late adulthood.  The most common anatomic site for this lesion is the upper leg or buttock.  They can arise from an area on the skin that has been irradiated or has a long standing ulcer.  The prognosis depends on the depth and how closely the lesion is to the trunk, with those that are deep and near the trunk being the most aggressive.  Treatment involves surgical excision or Mohs surgery.