Adult Linear IgA Disease is a skin blistering disease that I rarely encounter in both my The Woodlands dermatology and Conroe dermatology offices. Clinically, Adult Linear IgA Disease presents as either small vesicles similar to dermatitis herpetiformis or larger tense bullae as in bullous pemphigoid. The oral mucosa is involved in half of all patients with this disease. The etiology of this skin disease is an IgA mediated attack against the basement membrane of the dermo-epidermal junction. In some cases, medicines are implicated as the causative agent: lithium, vancomycin, lasix, PUVA, interferon, dilantin, statins, ace inhibitors, and amidodarone. Treatment involves stopping the offending agent and immunosuppressive therapy.
