Indeterminate Cell Histiocytosis is a rare type of Non-X Histiocytosis that I occasionally encounter in both my The Woodlands dermatology and Conroe dermatology offices. Indeterminate cells are the precursors of Langerhans cells but lack the distinctive intracellular Birbeck granules. Indeterminate Cell Histiocytosis is most common in males and occurs equally across all ages. Clinically, Indeterminate Cell Histiocytosis appears as yellow/red/brown papules and nodules on the skin. Rarely, does Indeterminate Cell Histiocytosis involve internal organs and the bones. In severe cases, chemotherapy has been successfully used as a treatment.
